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Comprehensive Fermentation Services
We understand that the road to an efficient commercial manufacturing process starts with the right process development program. Our multi-disciplinary process development team is constantly focusing on economic viability, robustness, scalability and conformation to the regulatory requirements of the processes right from the beginning. Collectively, our process development teams in the Czech Republic and Switzerland have some of the most extensive fermentation know-how in the industry, having developed over 100 processes, 25 of them large-scale.
Process Development Services
– Strain design and selection
– Strain characterization
– cGMP cell banking
– Fermentation and recovery development
– Refold optimization
– Filtration and chromatography development
– A full range of analytical support
XS Microbial Expression Technologies™
Based on 25 years of innovation in microbial biotechnology, Lonza has established XS Microbial Expression Technologies™ as an advanced and versatile microbial fermentation production platform.
XS Technologies™ encompass a diverse assembly of expression systems that not only deliver high expression levels but also quickly enable the creation of a productive and efficient cGMP process. For more information, click here.
Microbiological Experience
E. coli, Pichia, Hansenula, Pseudomonas, Saccharomyces, Aspergillus, Bacillus, Streptomyces, Trichoderma, and a dozen other microbial species, including BSL-2 organisms. |
Strain Design
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Besides classic mutagenesis in combination with high throughput screening, Lonza has developed its own expression platform for Escherichia coli. Furthermore, Lonza is involved as an industrial partner in a strain development program for Pseudomonas as production host in the framework of an international EU project. Yeast or fungal systems might be additional alternatives to prokaryotic hosts. For example, methylotrophic yeasts, such as Pichia pastoris and Hansenula polymorpha, have become highly successful systems for the expression of heterologous genes.
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Based upon a customer’s requirement, Lonza Custom Manufacturing will set up a strain design screening program to develop new organisms of industrial interest and offer expertise in cloning, mutagenesis, metabolic pathway engineering and enzymatic reactions (in solution or immobilized). On request, Lonza also improves customer production strains.
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Cell Banking
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Lonza Custom Manufacturing has dedicated cGMP units within the manufacturing facilities to create Master and Working Cell Banks for subsequent manufacture. For safety reasons, dual-site cGMP cell bank storage is offered to all customers. In addition, Lonza Custom Manufacturing offers cell line characterization services and full documentation that meets regulatory standards.
For any further requests or inquiries, please contact our experts.
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